Week 1 of the 2025 college football season delivers a powerhouse slate of matchups that could shape the playoff race from the start. Headliners include a rare No. 1 vs. No. 3 showdown as Texas visits Ohio State, LSU clashing with Clemson in another top-10 battle, and Notre Dame heading to Miami for a primetime thriller. Alabama travels to Florida State in a potential upset alert, while Coach Deion Sanders’ Colorado debut against Georgia Tech adds extra buzz. With conference bragging rights, playoff positioning, and fresh storylines on the line, opening weekend promises drama, intensity, and must-watch action across the country.